diff --git a/drivers/iommu/amd/iommu.c b/drivers/iommu/amd/iommu.c
index 29ae44513cf6..695cfb2e56aa 100644
--- a/drivers/iommu/amd/iommu.c
+++ b/drivers/iommu/amd/iommu.c
@@ -1441,7 +1441,8 @@ static void __domain_flush_pages(struct protection_domain *domain,
 static void domain_flush_pages(struct protection_domain *domain,
 			       u64 address, size_t size, int pde)
 {
-	if (likely(!amd_iommu_np_cache)) {
+	if (likely(!amd_iommu_np_cache) ||
+		size >= (1ULL<<52)) {
 		__domain_flush_pages(domain, address, size, pde);
 		return;
 	}