diff --git a/src/if_python.c b/src/if_python.c
index 1d87cac4d2..1ab8d756df 100644
--- a/src/if_python.c
+++ b/src/if_python.c
@@ -932,7 +932,10 @@ Python_Init(void)
 #endif
 
 #ifdef PYTHON_HOME
-	Py_SetPythonHome(PYTHON_HOME);
+# ifdef DYNAMIC_PYTHON
+	if (mch_getenv((char_u *)"PYTHONHOME") == NULL)
+# endif
+	    Py_SetPythonHome(PYTHON_HOME);
 #endif
 
 	init_structs();
diff --git a/src/if_python3.c b/src/if_python3.c
index 721e3cc5bb..387b811f61 100644
--- a/src/if_python3.c
+++ b/src/if_python3.c
@@ -858,7 +858,10 @@ Python3_Init(void)
 
 
 #ifdef PYTHON3_HOME
-	Py_SetPythonHome(PYTHON3_HOME);
+# ifdef DYNAMIC_PYTHON3
+	if (mch_getenv((char_u *)"PYTHONHOME") == NULL)
+# endif
+	    Py_SetPythonHome(PYTHON3_HOME);
 #endif
 
 	PyImport_AppendInittab("vim", Py3Init_vim);